Category: Exploring Frontiers With Computational Power

The Holehouse Lab is decoding one of biology’s most persistent blind spots: intrinsically disordered regions (IDRs) of proteins. Supported by the high-performance computing and storage resources of WashU IT’s Research Infrastructure Services (RIS), the lab recently published groundbreaking research in Nature. Their paper, “Accurate predictions of disordered protein ensembles with STARLING,” leverages a large protein-language […]

Mission:  While not synonymous with Precision Medicine, Precision Genomics plays a crucial role within its broader scope alongside fields like Precision Psychiatry and Precision Imaging. As a research lab, the Turner Lab is dedicated to advancing Precision Genomics by tackling five key challenges (in the image above) that currently limit its application for everyone. Resulted Success:  In the […]

Mission: Developing innovative, focused ultrasound technology for applications evolving the brain. This makes ultrasounds more affordable, portable, and noninvasive, allowing for interfacing with the brain without surgery.  Objective: To transform the process of neurosurgery and introduce the concept of using ultrasound technology in neuroscience to study how the brain functions non-invasively.  Resulted Success: Published last September, the […]

Background: Characterizing air quality from global to local scales by gathering satellite remote sensing or other observational data and applying the GEOS-Chem model to simulate the atmosphere, interpret those observations, and understand processes that enable prediction.  Relevance: Driven strongly by the effects of air quality on human health.  Objective: To understand the traditional sources and processes that […]

 Background: Basic biology of how mutations and acute myeloid leukemia contribute to the development of cancer. Specifically, genomics, how genes are regulated, and epigenetic modifications that regulate genes to understand processes in leukemia. Relevance: Having a better understanding of how cancer works to predict how patients will respond to therapies and finding pathways that could target new […]